TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE

TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE - Names and Identifiers

Name	2-(Boc-amino)-4-bromopyridine
Synonyms	2-(Boc-amino)-4-bromopyridine t-Butyl 4-bromopyridin-2-ylcarbamate tert-Butyl 4-bromopyridin-2-ylcarbamate TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE ert-butylN-(4-bromopyridin-2-yl)carbamate tert-Butyl N-(4-bromo-2-pyridyl)carbamate tert-butyl N-(4-broMopyridin-2-yl)carbaMate (4-Bromo-pyridin-2-yl)-carbamic acid tert-butyl ester CarbaMicacid,N-(4-broMo-2-pyridinyl)-,1,1-diMethylethylester
CAS	207799-10-8
EINECS	817-281-8
InChI	InChI=1/C10H13BrN2O2/c1-10(2,3)15-9(14)13-8-6-7(11)4-5-12-8/h4-6H,1-3H3,(H,12,13,14)

TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE - Physico-chemical Properties

Molecular Formula	C10H13BrN2O2
Molar Mass	273.13
Density	1.453±0.06 g/cm3(Predicted)
Boling Point	296.7±25.0 °C(Predicted)
Flash Point	133.239°C
Vapor Presure	0.001mmHg at 25°C
pKa	11.89±0.70(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
Refractive Index	1.573

TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE - Reference Information

Use

tert-butyl (4-bromopyrimidin-2-yl) carbamate is useful as a pharmaceutical synthesis intermediate.

preparation

tert-butyl (4-bromopyrimidin-2-yl) carbamate can be prepared from 4-bromopyridin-2-amine, di-tert-butyl carbonate ((Boc)2O), 4-dimethylaminopyridine reaction, can be used for the preparation of ALD derivatives, for the treatment of EV71 and CAV16 infection and its caused by hand, foot and mouth disease and related complications.
to a 250 ml round-bottom bottle was added 4-bromopyridin-2-amine (5g,28.90mmol), di-tert-butyl carbonate ((Boc)2O)(6.8g,31.16mmol), 4-dimethylaminopyridine (0.32g), tert-butanol (tert-Butanol)(70ml). Stir overnight at room temperature, concentrate in vacuo, and the resulting mixture is washed with 30ml hexane/ether in a volume ratio of 5:1 to give tert-butyl (4-bromopyrimidin-2-yl) carbamate (tert-butylN-(4-bromopyridin-2-yl)carbamate)(4.5g,57%) as a white solid.

Last Update：2024-04-09 21:01:54